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KMID : 0371619880040010057
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Journal of Wonkwang Medical Science
1988 Volume.4 No. 1 p.57 ~ p.64
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Effects of Atrial Distension on the Atria-Specific Granules in Rat Cardiocyte
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Cho Yoo-Young
Choi Min-Kyu
Chung Yeun-Tai
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Abstract
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The right atrium is known to play a role in blood volume homeostasis, secreating a peptido that induces a potent natriuresis and diuresis. This peptide is atrial natriuretic peptide (ANP)and its primary site of storage is within the granules found in cardiocytes of right atrium. To investigate the release of atria-specific granules after atrial distension, an electron microscopic study was done on the rat cardiocytes. Sprague-Dawley rats weighing 250-300g were anesthetized with nembutal. In order to induce atrial distension, 5% dextrose solution was injected by one fourh of body fluid via femoral vein. Atria-Specific granules were found in the sarcoplasm at the nuclear poles of right atrial cardiocytes. The granules which possess a homogenous, electron dense core, are surrounded by a limiting membrane, and measure 200-500 ㎚ in diameter. However, the granules located close to the Golgi apparatus, were often noted close to the sarcolemma. The atrial distension caused significant increase in the number and density of atria-Specific granules of rat cardiocytes. These results indicate that atrial distension may accelerate synthesis and release of the atria-Specific granules.
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